Journal article
Cost of whole genome sequencing for non-typhoidal Salmonella enterica
L Ford, K Glass, DA Williamson, V Sintchenko, JMB Robson, E Lancsar, R Stafford, MD Kirk
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2021
Abstract
Background While whole genome sequencing (WGS) may be more expensive than traditional testing and polymerase chain reaction (PCR), simple cost comparisons ignore the potential for WGS to reduce the societal costs of non-typhoidal Salmonella enterica through public health action to prevent illness. Methods We determined how many cases the use of WGS data would need to prevent to be costequal to serotyping and MLVA, or culture independent testing based on PCR in Australia. We then examined the costs and cost-savings of current typing methods compared with WGS in outbreak scenarios. Results A median of 275 (90% CrI-55-775) or 1.9% (90% CrI-0.4%-5.4%) of notified serotyped Salmonella cases would..
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Awarded by National Health & Medical Research Council
Funding Acknowledgements
Laura Ford is supported by an Australian Government Research Training Program (RTP) Scholarship. The National Health & Medical Research Council provided research fellowship funding for Martyn D. Kirk (APP1145997), Deborah A. Williamson (APP1123854) and Vitali Sintchenko (APP1123879). Jennifer M.B. Robson is employed by Sullivan Nicolaides Pathology. These funders provided support in the form of salaries for authors LF, MDK, DAW, VS and JMBR, but did not have any additional role in the study design, data collection and analysis, decision to published, or preparation of the manuscript. The specific roles of these authors are articulated in the `author contributions' section.